The thrombin receptor elevates intracellular calcium in adult rat ventricular myocytes.

@article{Jiang1998TheTR,
  title={The thrombin receptor elevates intracellular calcium in adult rat ventricular myocytes.},
  author={T Jiang and Peter R Danilo and Susan F. Steinberg},
  journal={Journal of molecular and cellular cardiology},
  year={1998},
  volume={30 11},
  pages={2193-9}
}
While there is evidence that thrombin receptor activation leads to contractile dysfunction and induces arrhythmias in ischemic/reperfused cardiac tissue, thrombin is variably reported to modulate intracellular calcium in cardiomyocytes. The present study demonstrates that thrombin receptor activation leads to a rise in intracellular calcium in adult ventricular myocytes and serves to reconcile previous discrepant findings. The thrombin receptor-derived agonist peptide (SFLLRN, a portion of the… CONTINUE READING
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