The thrifty phenotype: An adaptation in growth or metabolism?

@article{Wells2011TheTP,
  title={The thrifty phenotype: An adaptation in growth or metabolism?},
  author={J. Wells},
  journal={American Journal of Human Biology},
  year={2011},
  volume={23}
}
  • J. Wells
  • Published 2011
  • Biology, Medicine
  • American Journal of Human Biology
  • The thrifty phenotype hypothesis is widely used to interpret associations between early nutritional experience and degenerative disease risks. However, it remains unclear what is adaptive about early life thrift, and biomedical approaches struggle to explain why associations between early growth and later disease hold across the entire range of birth size. This issue can be addressed using a simple model, attributing disease to a high metabolic load (large tissue masses, rich diet, and… CONTINUE READING
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