The thrifty phenotype: An adaptation in growth or metabolism?
@article{Wells2011TheTP, title={The thrifty phenotype: An adaptation in growth or metabolism?}, author={J. Wells}, journal={American Journal of Human Biology}, year={2011}, volume={23} }
The thrifty phenotype hypothesis is widely used to interpret associations between early nutritional experience and degenerative disease risks. However, it remains unclear what is adaptive about early life thrift, and biomedical approaches struggle to explain why associations between early growth and later disease hold across the entire range of birth size. This issue can be addressed using a simple model, attributing disease to a high metabolic load (large tissue masses, rich diet, and… CONTINUE READING
Topics from this paper
165 Citations
The diabesity epidemic in the light of evolution: insights from the capacity–load model
- Biology, Medicine
- Diabetologia
- 2019
- 9
- PDF
Obesity as malnutrition: The role of capitalism in the obesity global epidemic
- Biology, Medicine
- American journal of human biology : the official journal of the Human Biology Council
- 2012
- 92
- PDF
A link between thrifty phenotype and maternal care across two generations of intercrossed mice
- Biology, Medicine
- PloS one
- 2017
- 5
- PDF
Elucidation of thrifty features in adult rats exposed to protein restriction during gestation and lactation
- Biology, Medicine
- Physiology & Behavior
- 2012
- 27
An evolutionary perspective on the trans-generational basis of obesity
- Biology, Medicine
- Annals of human biology
- 2011
- 27
Worldwide variability in growth and its association with health: Incorporating body composition, developmental plasticity, and intergenerational effects
- Biology, Medicine
- American journal of human biology : the official journal of the Human Biology Council
- 2017
- 19
- PDF
The childhood obesity epidemic as a result of nongenetic evolution: the maternal resources hypothesis.
- Biology, Medicine
- Mayo Clinic proceedings
- 2015
- 54
- PDF
Body composition and susceptibility to type 2 diabetes: an evolutionary perspective
- Biology, Medicine
- European Journal of Clinical Nutrition
- 2017
- 18
- PDF
References
SHOWING 1-10 OF 152 REFERENCES
The thrifty phenotype as an adaptive maternal effect
- Medicine, Biology
- Biological reviews of the Cambridge Philosophical Society
- 2007
- 232
The thrifty phenotype hypothesis: thrifty offspring or thrifty mother?
- Biology, Medicine
- Journal of theoretical biology
- 2003
- 232
Maternal capital and the metabolic ghetto: An evolutionary perspective on the transgenerational basis of health inequalities
- Biology, Medicine
- American journal of human biology : the official journal of the Human Biology Council
- 2010
- 184
Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms
- Biology, Medicine
- International Journal of Obesity
- 2009
- 84
- PDF
Insights from the developing world: thrifty genotypes and thrifty phenotypes.
- Biology, Medicine
- The Proceedings of the Nutrition Society
- 2005
- 181
- PDF
Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance.
- Biology, Medicine
- Best practice & research. Clinical endocrinology & metabolism
- 2008
- 111
- PDF
Fetal origins of developmental plasticity: Are fetal cues reliable predictors of future nutritional environments?
- Biology, Medicine
- American journal of human biology : the official journal of the Human Biology Council
- 2005
- 315
- PDF
Developmental origins of metabolic disease: life course and intergenerational perspectives
- Biology, Medicine
- Trends in Endocrinology & Metabolism
- 2010
- 366
- Highly Influential