The three mechanisms of intracellular chloride accumulation in vascular smooth muscle of human umbilical and placental arteries

@article{Chien2000TheTM,
  title={The three mechanisms of intracellular chloride accumulation in vascular smooth muscle of human umbilical and placental arteries},
  author={P. Chien and A. R. Chipperfield and A. Gordon and Alexander A. Harper},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={441},
  pages={150-154}
}
Recordings of membrane potential (E m) and intracellular [Cl–] ([Cl–]i) were made from the smooth muscle of human umbilical and placental arteries, using double-barrelled, ion-sensitive microelectrodes. In both arteries, [Cl–]i was above equilibrium with E m. In the umbilical artery, [Cl–]i was 33.8±0.9 mM (±SD, n=19) and E m –54.9±1.3 mV and in the placental artery respectively 35.1±0.7 mM (n=17) and –50.6±0.9 mV. In both arteries, [Cl-]i was reduced and E m hyperpolarised significantly by… CONTINUE READING
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