The three leg imaginal discs of Drosophila: "Vive la différence".

  title={The three leg imaginal discs of Drosophila: "Vive la diff{\'e}rence".},
  author={Gerold Schubiger and Margrit Schubiger and Anne Sustar},
  journal={Developmental biology},
  volume={369 1},

The Drosophila genes disconnected and disco-related together specify development of adult legs

It is concluded from these studies that the disco genes promote leg development through regulation of signaling processes, but also by stabilizing expression of the leg determination gene network.

The legacy of Drosophila imaginal discs

Key discoveries resulting from investigations of Drosophila epithelial precursor organs are reviewed, ranging from cell fate determination and transdetermination to tissue patterning.

Characterisation of the role and regulation of Ultrabithorax in sculpting fine-scale leg morphology

The role and regulation of Ultrabithorax (Ubx) during leg development in Drosophila melanogaster is analysed to provide insights into how Ubx is integrated into a postembryonic gene regulatory network to determine fine-scale leg morphology.

A Distalless-responsive enhancer of the Hox gene Sex combs reduced is required for segment- and sex-specific sensory organ development in Drosophila

This work has identified two cis-regulatory elements that control spatially modulated Scr expression within T1 legs and shows that this enhancer functions to integrate Scr into the intrasegmental gene regulatory network, such that Scr serves as a link between leg patterning, sex determination, and sensory organ development.

Single-Cell Atlas of the Drosophila Leg Disc Identifies a Long Non-Coding RNA in Late Development

The role of a novel lncRNA in Drosophila leg development is explored by dissecting and dissociating w1118 third-instar larval third leg (L3) discs into single cells and single nuclei, and performing single-cell RNA-sequencing and single- cell assays for transposase-accessible chromatin (scATAC-seq).

Imaginal Disc Transplantation in Drosophila.

A protocol for imaginal disc transplantation is described and recommendations on the procedure in particular for analyzing the regenerative potential of imaginal disks are provided.

Micromanagement of Drosophila Post-Embryonic Development by Hox Genes

It is argued that further investigating the regulation and roles of Hox genes in Drosophila post-embryonic development has great potential for understanding gene regulation, cell fate and phenotypic differentiation more generally.

The Centrosome as a Geometry Organizer.

  • M. Regolini
  • Biology
    Results and problems in cell differentiation
  • 2019
The centrosome, through its aster of microtubules, possesses all the characteristics necessary to operate as a biophysical geometric compass: it could recognize cargoes equipped with topogenic sequences and drive them precisely to where they are addressed (as hypothesized by Albrecht-Buehler nearly 40 years ago).

Epithelial tissue folding pattern in confined geometry

A three-dimensional vertex model that expresses tissue deformations based on cell mechanical behaviors is employed and results suggest that the orientation of the axis of cell division is sufficient to cause different folding patterns in silico and that the restraint of out-of-plane deformation due to the confined geometry determines the interspacing of the folds.

Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors

A genome-wide view is provided of how Hox paralogs, and perhaps par analogs of other transcription factor families, orchestrate alternative downstream gene networks and suggest the importance of multiple, context-specific cofactors.



Hox gene control of segment-specific bristle patterns in Drosophila.

The study of how the Hox gene Ultrabithorax controls specific differences between the bristle patterns of the second and third thoracic segments of Drosophila melanogaster finds that Ubx blocks the development of two particular bristles on T3 at different points in sensory organ development.

Bristle patterns and compartment boundaries in the tarsi of Drosophila.

The results support the selector gene model of development (Garcia-Bellido, 1975) and emphasize that collaboration between polyclones is important in pattern formation.

Transdetermination in leg imaginal discs ofDrosophila melanogaster undDrosophila nigromelanica

The homeotic mutation Polycomb (Pc3) which partially transforms meso- and metathoracic legs into prothoracics legs did not significantly increase the frequencies of transdetermination in these leg dises and had clearly no effect on the direction of trans determination.

The spatial organization of epidermal structures: hairy establishes the geometrical pattern of Drosophila leg bristles by delimiting the domains of achaete expression.

The leg bristle pattern is apparently regulated at two levels: a global regulation of the hairy and achaete expression patterns which partitions the leg epidermis into striped zones and a local regulation that involves refinement steps which may control the alignment and spacing of bristle cells within these zones.

Genes controlling segmental specification in the Drosophila thorax.

  • G. Struhl
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1982
It is argued strongly that segmental determination is specified in a combinatorial fashion in the head and thorax by the selective activities of the Scr+, Ubx+, Antp+, and putative head-determining genes.

Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum

A homologue of the Drosophila wingless gene, a mediator of cell–cell communications7–9, is isolated from the short-germ beetle Tribolium castaneum to compare the molecular mechanisms of segmentation.

Non-Redundant Selector and Growth-Promoting Functions of Two Sister Genes, buttonhead and Sp1, in Drosophila Leg Development

These observations suggest that an ancient Sp8/Dlx gene cassette was used in an early metazoan for primitive limb-like outgrowths and that this cassette was co-opted multiple times for appendage formation in multiple animal phyla.