The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

@article{Daskalakis2013TheTC,
  title={The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.},
  author={Nikolaos P Daskalakis and Rosemary C. Bagot and Karen J Parker and Christiaan H Vinkers and E. Ron de Kloet},
  journal={Psychoneuroendocrinology},
  year={2013},
  volume={38 9},
  pages={1858-73}
}
Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Although this programming effect exerted by experience-related factors is an important determinant of mental health, its outcome depends on cognitive inputs and hence the valence an individual assigns to a given environmental context. From this perspective we will highlight, with… CONTINUE READING