The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori.

@article{Pang2014TheTS,
  title={The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori.},
  author={Siew Siew Pang and Stanley Thai Son Nguyen and Andrew J. Perry and Christopher J. Day and Santosh Panjikar and Joe Tiralongo and James C. Whisstock and Terry Kwok},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 10},
  pages={6332-40}
}
The gastric pathogen Helicobacter pylori is a major cause of acute chronic gastritis and the development of stomach and duodenal ulcers. Chronic infection furthermore predisposes to the development of gastric cancer. Crucial to H. pylori survival within the hostile environment of the digestive system are the adhesins SabA and BabA; these molecules belong to the same protein family and permit the bacteria to bind tightly to sugar moieties Lewis(B) and sialyl-Lewis(X), respectively, on the… CONTINUE READING
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