The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.

@article{Liu1999TheTS,
  title={The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.},
  author={Z Liu and Maria J. Macias and Matthew James Bottomley and Gunter Stier and Jens P. Linge and Michael Nilges and Peer Bork and Michael Sattler},
  journal={Structure},
  year={1999},
  volume={7 12},
  pages={1557-66}
}
BACKGROUND The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their function… CONTINUE READING

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