The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain.

@article{Housset1997TheTS,
  title={The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain.},
  author={Dominique Housset and Gilbert Mazza and Claude Gr{\'e}goire and Claudine Piras and Bernard Malissen and Juan C Fontecilla-Camps},
  journal={The EMBO journal},
  year={1997},
  volume={16 14},
  pages={4205-16}
}
The crystal structure of a mouse T-cell antigen receptor (TCR) Fv fragment complexed to the Fab fragment of a specific anti-clonotypic antibody has been determined to 2.6 A resolution. The polypeptide backbone of the TCR V alpha domain is very similar to those of other crystallographically determined V alphas, whereas the V beta structure is so far unique among TCR V beta domains in that it displays a switch of the c" strand from the inner to the outer beta-sheet. The beta chain variable region… CONTINUE READING