The three-dimensional organization of ribosomal genes and the architecture of the nucleoli vary with G1, S and G2 phases.

@article{Junra1995TheTO,
  title={The three-dimensional organization of ribosomal genes and the architecture of the nucleoli vary with G1, S and G2 phases.},
  author={Henriette Roberte Jun{\'e}ra and Claude Masson and Gilles G{\'e}raud and Dani{\'e}le Hernandez-Verdun},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 11)},
  pages={3427-41}
}
The three-dimensional (3-D) organization of the nucleolus, a defined nuclear territory containing tandem repeats of the ribosomal genes (rDNA), was investigated in PtK1 cells. Identification of the interphase stages was performed in single cells using DNA quantification by cytometry for the G1 and G2 phases while the S phase was identified by immunolabelling of the proliferating cell nuclear antigen (PCNA). The 3-D organization of the rDNA in the nucleolus was analyzed by fluorescence in situ… CONTINUE READING

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