The three asparaginases. Comparative pharmacology and optimal use in childhood leukemia.

@article{Asselin1999TheTA,
  title={The three asparaginases. Comparative pharmacology and optimal use in childhood leukemia.},
  author={Barbara L. Asselin},
  journal={Advances in experimental medicine and biology},
  year={1999},
  volume={457},
  pages={621-9}
}
Asparaginase (ASP) is a standard component of the antileukemia armamentarium. There are currently 3 preparations of asparaginase available: (1) E. coli (ASP, Elspar); (2) the enzyme derived from Erwinia chrysanthemi (ERW, Erwinase); (3) pegaspargase (PEG, Oncaspar), the E. coli enzyme modified by covalent attachment of polyethylene glycol. This report describes the findings of 3 pharmacologic end points: ASP enzyme activity in patients' sera, depletion of asparagine and the development of anti… CONTINUE READING