The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development.

@article{Kahane2001TheTW,
  title={The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development.},
  author={Nitza Kahane and Yuval Cinnamon and Ido Bachelet and Chaya Kalcheim},
  journal={Development},
  year={2001},
  volume={128 12},
  pages={2187-98}
}
The myotome is formed by a first wave of pioneer cells originating from the entire dorsomedial region of epithelial somites and a second wave that derives from all four lips of the dermomyotome but generates myofibers from only the rostral and caudal edges. Because the precedent progenitors exit the cell cycle upon myotome colonization, subsequent waves must account for consecutive growth. In this study, double labeling with CM-DiI and BrdU revealed the appearance of a third wave of progenitors… CONTINUE READING
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