The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.

@article{Chee2008TheTI,
  title={The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.},
  author={Melissa J. S. Chee and Karin M{\"o}rl and Diana Lindner and Nicole Merten and Gerald W Zamponi and Peter E. Light and Annette G Beck-Sickinger and William F. Colmers},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 48},
  pages={33337-46}
}
Constitutively active G-protein-coupled receptors (GPCRs) can signal even in the absence of ligand binding. Most Class I GPCRs are stabilized in the resting conformation by intramolecular interactions involving transmembrane domain (TM) 3 and TM6, particularly at loci 6.30 and 6.34 of TM6. Signaling by Gi/Go-coupled receptors such as the Neuropeptide Y1 receptor decreases already low basal metabolite levels. Thus, we examined constitutive activity using a biochemical assay mediated by a Gi/Gq… CONTINUE READING

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