The third intracellular loop plays a critical role in bitter taste receptor activation.

@article{Pydi2014TheTI,
  title={The third intracellular loop plays a critical role in bitter taste receptor activation.},
  author={Sai Prasad Pydi and Nisha Singh and Jasbir D. Upadhyaya and Rajinder Pal Bhullar and Prashen Chelikani},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 1 Pt B},
  pages={231-6}
}
Bitter taste receptors (T2Rs) belong to the superfamily of G protein-coupled receptors (GPCRs). T2Rs are chemosensory receptors with important therapeutic potential. In humans, bitter taste is perceived by 25 T2Rs, which are distinct from the well-studied Class A GPCRs. The activation mechanism of T2Rs is poorly understood and none of the structure-function studies are focused on the role of the important third intracellular loop (ICL3). T2Rs have a unique signature sequence at the cytoplasmic… CONTINUE READING