The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.

@article{Chakir2003TheTI,
  title={The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.},
  author={Khalid Chakir and Yang Xiang and Dongmei Yang and Sheng-jun Zhang and Heping Cheng and Brian K. Kobilka and Rui-ping Xiao},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 5},
  pages={
          1048-58
        }
}
It is well established that the beta2-adrenergic receptor (beta2-AR) exhibits a robust ligand-independent activity, whereas this property is considerably weaker in the closely related beta1-AR subtype. To identify the potential domain(s) of beta2-AR responsible for the spontaneous receptor activation, we created three chimeras in which the third intracellular loop (beta1/beta2-Li3) or the carboxyl terminus (beta1/beta2-CT) or both domains (beta1/beta2-Li3CT) of beta1-AR are replaced by the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Similar Papers

Loading similar papers…