The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.

@article{Schmidlin2003TheTI,
  title={The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.},
  author={Fabien Schmidlin and Dirk Roosterman and Nigel W Bunnett},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 4},
  pages={
          C945-58
        }
}
Tachykinins interact with three neurokinin receptors (NKRs) that are often coexpressed by the same cell. Cellular responses to tachykinins depend on the NKR subtype that is activated. We compared the colocalization of NK1R and NK3R with beta-arrestins 1 and 2, which play major roles in receptor desensitization, endocytosis, and signaling. In cells expressing NK1R, the selective agonist Sar-Met-substance P induced rapid translocation of beta-arrestins 1 and 2 from the cytosol to the plasma… CONTINUE READING
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