The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions

@article{Bruun2005TheTH,
  title={The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions},
  author={Jack-Ansgar Bruun and Ernst Ivan Simon Thomassen and Kurt Kristiansen and Garth D Tylden and Turid Holm and Ingvild Mikkola and Geir Bj\ork\oy and Terje Johansen},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={2661 - 2675}
}
The transcription factor Pax6 is essential for the development of the eyes and the central nervous system of vertebrates and invertebrates. Pax6 contains two DNA-binding domains; an N-terminal paired domain and a centrally located homeodomain. We have previously shown that the vertebrate paired-less isoform of Pax6 (Pax6DeltaPD), and several other homeodomain proteins, interact with the full-length isoform of Pax6 enhancing Pax6-mediated transactivation from paired domain-DNA binding sites. By… CONTINUE READING

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