The third/second generation PTH assay ratio as a marker for parathyroid carcinoma: evaluation using an automated platform.

@article{Cavalier2014TheTG,
  title={The third/second generation PTH assay ratio as a marker for parathyroid carcinoma: evaluation using an automated platform.},
  author={Etienne Cavalier and Daniela Betea and Marie-Louise Schleck and Romy Gadisseur and Laurent Vroonen and Pierre Delanaye and Adrian F Daly and Albert M. Beckers},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 3},
  pages={E453-7}
}
BACKGROUND Parathyroid carcinoma (PCa) is rare and often difficult to differentiate initially from benign disease. Because PCa oversecretes amino PTH that is detected by third-generation but not by second-generation PTH assays, the normal 3rd/2nd generation PTH ratio (<1) is inverted in PCa (ie, >1). OBJECTIVE The objective of the investigation was to study the utility and advantages of automated 3rd/2nd generation PTH ratio measurements using the Liaison XL platform over existing manual… CONTINUE READING
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