The thioredoxin system—From science to clinic

@article{Gromer2004TheTS,
  title={The thioredoxin system—From science to clinic},
  author={Stephan Gromer and Sabine Urig and Katja Becker},
  journal={Medicinal Research Reviews},
  year={2004},
  volume={24}
}
The thioredoxin system—formed by thioredoxin reductase and its characteristic substrate thioredoxin—is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA‐synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine—ranging from infectious diseases to cancer therapy. In this review… 
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355 Citations
Highly Influential Citations
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Background Citations
81
Methods Citations
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Results Citations
2

355 Citations

The thioredoxin system and cancer therapy: a review
TLDR
The features and functions of the Trx system are described and then its correlations with cancer are reviewed and the present knowledge about the TrX/TrxR inhibitors as anticancer drugs are summarized.
Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents
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The current knowledge on metal- and semimetal-containing molecules capable of hampering mammalian TrxRs is summarized, with an emphasis on compounds reported in the last decade.
Small molecule inhibitors of mammalian thioredoxin reductase.
Perspectives of TrxR1-based cancer therapies
Thioredoxin and related molecules--from biology to health and disease.
TLDR
Thioredoxin and binding proteins appear to control apoptosis or metabolic states such as carbohydrate and lipid metabolism related to diseases such as diabetes and atherosclerosis and the fundamental differences between bacterial and mammalian thiOREDoxin reductases offer new principles for treatment of infections.
Natural product based inhibitors of the thioredoxin-thioredoxin reductase system.
Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be…
The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy
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Findings suggest that the TRX/TX system may represent an attractive target for development of new cancer therapeutics.
The thioredoxin system in cancer.
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
Selective inhibition of extracellular thioredoxin by asymmetric disulfides.
TLDR
The most active compound identified had an IC(50) below 0.1 μM in cell culture and may be appropriate for in vivo use to interrogate the role of extracellular Trx in health and disease.
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TLDR
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TLDR
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TLDR
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