The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy.

@article{Biaglow2005TheTR,
  title={The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy.},
  author={John E. Biaglow and Richard A Miller},
  journal={Cancer biology & therapy},
  year={2005},
  volume={4 1},
  pages={
          6-13
        }
}
Thioredoxin reductase (TRX) is a selenoprotein that reduces oxidized protein substrates in an NADPH-dependent process (cf. Fig. 1). The thioredoxins (TX) are a family of small redox active proteins that undergo reversible oxidation/reduction and help to maintain the redox state of cells. TX serves as a cofactor in many TRX-catalyzed reductions in a manner similar to glutathione (GSH) in thioltransferase reactions. For example, TX is a cofactor in protein disulfide reduction and DNA synthesis… CONTINUE READING

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