The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

@article{Welsh2003TheTR,
  title={The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.},
  author={Sarah J. Welsh and Ryan R Williams and Anne M. Birmingham and David J. Newman and D. Lynn Kirkpatrick and Garth Powis},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 3},
  pages={235-43}
}
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in tumor growth by increasing resistance to apoptosis and the production of angiogenic factors such as vascular endothelial growth factor (VEGF). HIF-1 is a heterodimer comprised of oxygen-regulated HIF-1alpha and constitutively expressed HIF-1beta subunits. The redox… CONTINUE READING