The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.

@article{Kohli2002TheTD,
  title={The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.},
  author={Rahul M Kohli and Junichi Takagi and Christopher T Walsh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 3},
  pages={1247-52}
}
Nonribosomal peptide synthetases responsible for the production of macrocyclic compounds often use their C-terminal thioesterase (TE) domain for enzymatic cyclization of a linear precursor. The excised TE domain from the nonribosomal peptide synthetase responsible for the production of the cyclic decapeptide tyrocidine A, TycC TE, retains autonomous ability to catalyze head-to-tail macrocyclization of a linear peptide thioester with the native sequence of tyrocidine A and can additionally… CONTINUE READING