The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.

@article{Marusak2016TheTS,
  title={The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.},
  author={Charles Marusak and Ian M. Bayles and Jun Ma and Major D Gooyit and Ming Jing Gao and Mayland Chang and Barbara Bedogni},
  journal={Pharmacological research},
  year={2016},
  volume={113 Pt A},
  pages={
          515-520
        }
}
MT1-MMP and MMP2 have been implicated as pro-tumorigenic and pro-metastatic factors in a wide variety of cancers including melanoma. We have previously demonstrated that MT1-MMP is highly expressed in melanoma where it promotes melanoma cell invasion and metastasis in part through the activation of its target MMP2. Given the accessibility of MMPs, as they… CONTINUE READING