The thermodynamic basis of the genetic code.

  title={The thermodynamic basis of the genetic code.},
  author={Horst H. Klump},
  journal={Free radical research communications},
  volume={6 2-3},
A systematic investigation of the helixcoil transition of DNA’s as a function of sequence composition has lead t o the conclusion that the Gibbs energy per base pair is a zero-order property. There is a correlation between the observed codon usage frequency and the codonlanti-codon interaction Gibbs energy per triplet. We will show that the bias of codon usage reflects strategies for efficiency and accuracy in gene expression. Organization beyond the codon triplets is discussed. THE TWO… CONTINUE READING
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