The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.

@article{Reis2013TheTP,
  title={The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.},
  author={Flaviana Ruade De Souza Reis and Fernanda C Casal de Faria and Carolina Pereira Castro and Paloma Silva de Souza and Flavia da Cunha Vasconcelos and Reinaldo D Bello and Alcides J da Silva and Paulo Roberto Costa and Raquel Ciuvalschi Maia},
  journal={Anti-cancer agents in medicinal chemistry},
  year={2013},
  volume={13 2},
  pages={341-51}
}
Acute myeloid leukemia (AML) is a challenging neoplasm that despite therapeutic advances requires efforts to overcome the multidrug resistance (MDR) phenotype, the major cause of relapse. The pterocarpanquinone LQB-118 is a new compound that induces apoptosis in leukemia cells. The objective of this work was to analyze the role of LQB-118 in inhibiting the inhibitor of apoptosis proteins (IAPs), XIAP and survivin, as well as in modulating the subcellular localization of NFκB, in comparison with… CONTINUE READING