The therapeutic use of androgens in women

@article{Davis1999TheTU,
  title={The therapeutic use of androgens in women},
  author={Susan R. Davis},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1999},
  volume={69},
  pages={177-184}
}
  • S. Davis
  • Published 1 April 1999
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
View on Elsevier
hormone.org
56 Citations
Highly Influential Citations
2
Background Citations
21
Results Citations
1

56 Citations

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The available literature suggests that low-dose testosterone treatment in women with androgen deficiency can have positive effects on libido and psychological well-being, and also may retard muscle and bone loss associated with aging.
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
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DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
Sex hormones and related compounds, including hormonal contraceptives
Hormone treatment for mood disorders in women
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There are preliminary, but promising data on the use of estradiol and testosterone for specific subpopulations, and further studies would help to better delineate the usage of these compounds as an antidepressant strategy (monotherapy or augmenting treatment).
Effect of Reproductive Hormones and Selective Estrogen Receptor Modulators on Mood during Menopause
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There are preliminary, though promising, data on the use of estradiol to alleviate depression during perimenopause, use of a combination of estrogens and selective serotonin reuptake inhibitors for depression during the postmenopausal period, and theUse of testosterone to improve psychological well-being and increase libido among women with induced menopause.
Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy.
Purpose: to evaluate the effects of the association of estrogen and androgen on the quality of life and sexuality of women
TLDR
Estrogen associated with methyltestosterone resulted in significant improvement in the quality of life and sexuality of postmenopausal women and was superior to estrogen alone and placebo.
Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
  • D. LiaoR. Dickson
  • Biology, Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2002
Preliminary Clinical Experience with Androgen Administration for Pre- and Postmenopausal Women with Hypoactive Sexual Desire
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It is suggested that testosterone may effectively alleviate hypoactive sexual desire, even in women with normal testosterone levels.
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References

SHOWING 1-10 OF 61 REFERENCES
Exogenous androgens in postmenopausal women.
The management of persistent menopausal symptoms with oestradiol-testosterone implants: clinical, lipid and hormonal results.
Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause.
TLDR
It was clear that exogenous androgen enhanced the intensity of sexual desire and arousal and the frequency of sexual fantasies in hysterectomized and oophorectomization women, but there was no evidence that testosterone affected physiologic response or interpersonal aspects of sexual behavior.
Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality.
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
TLDR
Repairing DHEA and DS to young adult levels in men and women of advancing age induced an increase in the bioavailability of IGF-I, as reflected by an increases in IGF- I and a decrease in IGFBP-1 levels.
HORMONAL DYNAMICS ASSOCIATED WITH THE MENOPAUSE
  • H. Judd
  • Medicine, Biology
    Clinical obstetrics and gynecology
  • 1976
TLDR
The current understanding of androgen estrogenand gonadotropin metabolism in menopausal women is reviewed and in postmenopausal women ovariectomy results in a small but significant decrease in circulating androstenedione.
Hormonal and pregnancy relationships to rheumatoid arthritis: convergent effects with immunologic and microvascular systems.
Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women.
TLDR
It is concluded that short term administration of androgen with estrogen may reverse the inhibitory effects of estrogen on bone formation and long term studies are needed to determine the relative benefits and risks of the combination of estrogen and androgen and whether this results in greater increases in bone mass and strength.
Oestrogen therapy and the menopausal syndrome.
TLDR
The improvement in memory and reduction of anxiety in these patients suggest that oestrogens have a direct tonic effect on the mental state which is independent of vasomotor symptoms, and it is likely that the cumulative effect of these small improvements results in an overall enhancement of well-being.
Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women.
TLDR
In all women bone mass was negatively associated with concentrations of sex-hormone binding globulin, and positively associated with weight, and with lower estrogens and androgens in peri- and postmenopausal women.
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