The therapeutic use of androgens in women

@article{Davis1999TheTU,
  title={The therapeutic use of androgens in women},
  author={Susan R. Davis},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1999},
  volume={69},
  pages={177-184}
}
  • S. Davis
  • Published 1 April 1999
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
View on Elsevier
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57 Citations
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22
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57 Citations

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  • J. MorleyH. Perry
  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2003
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The available literature suggests that low-dose testosterone treatment in women with androgen deficiency can have positive effects on libido and psychological well-being, and also may retard muscle and bone loss associated with aging.

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Clinically, it is effective and safe to perform a combination treatment of androgen replacement therapy in treating sexual dysfunction if medication is administered properly and carefully.

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.

TLDR
DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.

Sexuality in the climacteric years.

Treatment of female sexual dysfunction in postmenopausal women—What is the evidence?

Sex hormones and related compounds, including hormonal contraceptives

Hormone treatment for mood disorders in women

TLDR
There are preliminary, but promising data on the use of estradiol and testosterone for specific subpopulations, and further studies would help to better delineate the usage of these compounds as an antidepressant strategy (monotherapy or augmenting treatment).

Effect of Reproductive Hormones and Selective Estrogen Receptor Modulators on Mood during Menopause

TLDR
There are preliminary, though promising, data on the use of estradiol to alleviate depression during perimenopause, use of a combination of estrogens and selective serotonin reuptake inhibitors for depression during the postmenopausal period, and theUse of testosterone to improve psychological well-being and increase libido among women with induced menopause.

Treatment of Menopause-Related Mood Disturbances

TLDR
The current literature on the benefits and risks of using hormone therapy for the treatment of menopausal-related mood disturbances and alternate strategies currently available for the management of menopause-related problems are reviewed, including antidepressants, complementary and alternative medicine, and selective estrogen receptor modulators.
...

References

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Exogenous androgens in postmenopausal women.

The management of persistent menopausal symptoms with oestradiol-testosterone implants: clinical, lipid and hormonal results.

Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause.

TLDR
It was clear that exogenous androgen enhanced the intensity of sexual desire and arousal and the frequency of sexual fantasies in hysterectomized and oophorectomization women, but there was no evidence that testosterone affected physiologic response or interpersonal aspects of sexual behavior.

Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality.

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

TLDR
Repairing DHEA and DS to young adult levels in men and women of advancing age induced an increase in the bioavailability of IGF-I, as reflected by an increases in IGF- I and a decrease in IGFBP-1 levels.

HORMONAL DYNAMICS ASSOCIATED WITH THE MENOPAUSE

  • H. Judd
  • Medicine, Biology
    Clinical obstetrics and gynecology
  • 1976
TLDR
The current understanding of androgen estrogenand gonadotropin metabolism in menopausal women is reviewed and in postmenopausal women ovariectomy results in a small but significant decrease in circulating androstenedione.

Hormonal and pregnancy relationships to rheumatoid arthritis: convergent effects with immunologic and microvascular systems.

Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women.

TLDR
It is concluded that short term administration of androgen with estrogen may reverse the inhibitory effects of estrogen on bone formation and long term studies are needed to determine the relative benefits and risks of the combination of estrogen and androgen and whether this results in greater increases in bone mass and strength.

Oestrogen therapy and the menopausal syndrome.

TLDR
The improvement in memory and reduction of anxiety in these patients suggest that oestrogens have a direct tonic effect on the mental state which is independent of vasomotor symptoms, and it is likely that the cumulative effect of these small improvements results in an overall enhancement of well-being.

OESTRADIOL AND TESTOSTERONE IMPLANTS IN THE TREATMENT OF PSYCHOSEXUAL PROBLEMS IN THE POST‐MENOPAUSAL WOMAN

TLDR
The results in the ovarectomized women were not distinguishable from those with a spontaneous menopause, and no changes in the other hormone concentrations (including LH and FSH) were observed during three weeks of therapy.
...