The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control.

@article{Decker2001TheTP,
  title={The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control.},
  author={Michael W. Decker and Michael D. Meyer and James P. Sullivan},
  journal={Expert opinion on investigational drugs},
  year={2001},
  volume={10 10},
  pages={1819-30}
}
Due to the limitations of currently available analgesics, a number of novel alternatives are currently under investigation, including neuronal nicotinic acetylcholine receptor (nAChR) agonists. During the 1990s, the discovery of the antinociceptive properties of the potent nAChR agonist epibatidine in rodents sparked interest in the analgesic potential of this class of compounds. Although epibatidine also has several mechanism-related toxicities, the identification of considerable nAChR… CONTINUE READING

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