The therapeutic potential of microbial proteasome inhibitors.

  title={The therapeutic potential of microbial proteasome inhibitors.},
  author={Isao Momose and Manabu Kawada},
  journal={International immunopharmacology},
The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors are degraded by the proteasome… CONTINUE READING