The therapeutic potential of carbon monoxide

@article{Motterlini2010TheTP,
  title={The therapeutic potential of carbon monoxide},
  author={Roberto Motterlini and Leo E. Otterbein},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={728-743}
}
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin… 
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1,126 Citations
Highly Influential Citations
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1,126 Citations

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This chapter provides an overview of the many roles CO plays as a gasotransmitter in the cardiovascular system, including regulating blood pressure, smooth muscle cell proliferation, anti-inflammatory,Anti- apoptotic, and anti-coagulation effects.
Biological signaling by carbon monoxide and carbon monoxide-releasing molecules.
TLDR
How the binding of CO with key ferrous hemoproteins serves as a posttranslational modification that regulates important processes as diverse as aerobic metabolism, oxidative stress, and mitochondrial bioenergetics is discussed.
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The aim of this review is to discuss the potential therapeutic implications of CO with a focus on lung injury and sepsis-related models and co-treatment and post-treatment with CO.
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TLDR
The role of exogenous and endogenous CO (via HO activity and expression) in various CNS pathologies is focused upon, based upon data from experimental models, as well as from some clinical data on human patients.
Strategies toward Organic Carbon Monoxide Prodrugs.
TLDR
This Account describes the work in this area as well as the demonstration for these organic CO prodrugs to recapitulate CO's pharmacological effects both in vitro and in vivo and proposes a new concept of "enrichment triggered CO release" by conjugating both components with a mitochondria-targeting moiety to achieve targeted CO delivery with improved biological outcomes.
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