The therapeutic potential of carbon monoxide

@article{Motterlini2010TheTP,
  title={The therapeutic potential of carbon monoxide},
  author={R. Motterlini and L. Otterbein},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={728-743}
}
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin… Expand
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