The therapeutic potential of carbon monoxide

@article{Motterlini2010TheTP,
  title={The therapeutic potential of carbon monoxide},
  author={R. Motterlini and L. Otterbein},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={728-743}
}
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin… Expand
View on Nature
ncbi.nlm.nih.gov
910 Citations
Highly Influential Citations
47
Background Citations
285
Methods Citations
22
Results Citations
3

910 Citations

Citation Type

Citation Type

Carbon monoxide: a new pharmaceutical agent?
Therapeutic potential of carbon monoxide in multiple sclerosis
Therapeutic Aspects of Carbon Monoxide in Cardiovascular Disease
Carbon monoxide: mechanisms of action and potential clinical implications.
The role of carbon monoxide as a gasotransmitter in cardiovascular and metabolic regulation
Biological signaling by carbon monoxide and carbon monoxide-releasing molecules.
Carbon monoxide in the treatment of sepsis.
  • K. Nakahira, A. Choi
  • Chemistry, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
  • 2015
Therapeutic Applications of Carbon Monoxide
Carbon monoxide: a vital signalling molecule and potent toxin in the myocardium.
Carbon monoxide and the CNS: challenges and achievements
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 209 REFERENCES
Therapeutic applications of carbon monoxide-releasing molecules
Antimicrobial Action of Carbon Monoxide-Releasing Compounds
Use of carbon monoxide as a therapeutic agent: promises and challenges
Bioactivity and pharmacological actions of carbon monoxide-releasing molecules.
Heme oxygenase and carbon monoxide initiate homeostatic signaling
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
Bench-to-bedside review: Carbon monoxide – from mitochondrial poisoning to therapeutic use
Biological chemistry of carbon monoxide.
  • C. Piantadosi
  • Chemistry, Medicine
  • Antioxidants & redox signaling
  • 2002
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
  • Brian S. Zuckerbraun, Beek Yoke Chin, +4 authors Leo E. Otterbein
  • Medicine, Chemistry
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2007
Protective effects of a carbon monoxide-releasing molecule (CORM-3) during hepatic cold preservation.
...
1
2
3
4
5
...