The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

@article{Hudson2013TheTP,
  title={The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.},
  author={Brian D. Hudson and Trond Ulven and Graeme Milligan},
  journal={Current topics in medicinal chemistry},
  year={2013},
  volume={13 1},
  pages={
          14-25
        }
}
G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential. One in particular that has been gaining attention in recent times is that of GPCR ligands that bind to allosteric sites on the receptor distinct from the orthosteric site of the endogenous ligand. As therapeutics, allosteric ligands possess many… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 117 references

Functional characterization of human receptors for Short Chain fatty acids and their role in polymorphonuclear cell activation

E. Le Poul, C. Loison, +9 authors M. Detheux
J. Biol. Chem • 2003
View 14 Excerpts
Highly Influenced

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2012
View 1 Excerpt

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