The therapeutic orientation to clinical trials.

  title={The therapeutic orientation to clinical trials.},
  author={Franklin G. Miller and Donald Lee Rosenstein},
  journal={The New England journal of medicine},
  volume={348 14},
Traditionally, clinical trials have been understood as continuous with clinical medicine. 1 In providing medical care for patients, the physician makes observations, investigates, tests hypotheses, and experiments with different treatments. Moreover, the exemplary physician is always learning how to improve treatment for future patients on the basis of clinical experience with current patients and familiarity with the medical literature. Chalmers summarized this view as follows: “The practice… CONTINUE READING

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