The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study.

@article{Cano2012TheTE,
  title={The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study.},
  author={Ampaeli Cano and Jos{\'e} Manuel Estevez and Ram{\'o}n Usandizaga and Jos{\'e} Luis Gallo and Misericord Guinot and Juan Luis Delgado and Elena Castellanos and Eloy Moral and Concepci{\'o}n Nieto and Jaime Moscoso del Prado and Javier Diaz Ferrer},
  journal={Menopause},
  year={2012},
  volume={19 10},
  pages={1130-9}
}
OBJECTIVE The aim of this study was to evaluate the efficacy and safety of a new low-concentration estriol formulation (0.005% estriol vaginal gel), providing an ultra low dose of estriol per application (50 μg), for the local treatment of postmenopausal vaginal atrophy. METHODS Postmenopausal women with symptoms and signs of vaginal atrophy were enrolled in a prospective, double-blind, placebo-controlled study. Women received either 1 g of vaginal gel containing 50 μg of estriol or placebo… CONTINUE READING
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