The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity

  title={The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity},
  author={N. El-Shinnawy},
  journal={Toxicology and Industrial Health},
  pages={355 - 366}
  • N. El-Shinnawy
  • Published 2015
  • Chemistry, Medicine
  • Toxicology and Industrial Health
The present study investigated the impact of two doses, 500 mg/kg and 1000 mg/kg, of di(2-ethylhexyl) phthalate (DEHP) and studied the possible therapeutic dose of celery oil seed extract for 6 weeks on some atheroscelerogenic, obesogenic, antioxidant and liver functions in rats. Both doses of DEHP caused over-expression of peroxisome proliferator–activated receptor alpha (PPARα) messenger RNA with significant increase in liver weights, relative liver weights, serum cholesterol (Chol… Expand
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Celery (Apium graveolens L.), belonging to the family Apiaceae, is widely used as a spice, in perfumery and pharmaceutical applications. It is reported to possess several nutraceutical attributes,Expand
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Reversibility of the Chronic Effects of Di(2-ethylhexyl)phthalate
The extent of reversibility suggests that many chronic effects may be associated with a metabolic phenomenon such as peroxisome proliferation, which also reverted to control levels after 26 weeks of recovery. Expand
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Chronic toxicity of di(2-ethylhexyl)phthalate in rats.
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