The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity

@article{ElShinnawy2015TheTA,
  title={The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity},
  author={N. El-Shinnawy},
  journal={Toxicology and Industrial Health},
  year={2015},
  volume={31},
  pages={355 - 366}
}
  • N. El-Shinnawy
  • Published 2015
  • Chemistry, Medicine
  • Toxicology and Industrial Health
The present study investigated the impact of two doses, 500 mg/kg and 1000 mg/kg, of di(2-ethylhexyl) phthalate (DEHP) and studied the possible therapeutic dose of celery oil seed extract for 6 weeks on some atheroscelerogenic, obesogenic, antioxidant and liver functions in rats. Both doses of DEHP caused over-expression of peroxisome proliferator–activated receptor alpha (PPARα) messenger RNA with significant increase in liver weights, relative liver weights, serum cholesterol (Chol… Expand
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In the present study, the hepatoprotective activity of methanolic extract of Apium graveolens L. (celery) seeds was tested against Di-(2- ethylhexyl) phthalate (DEHP) induced hepatotoxicity in rats.Expand
The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats.
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The 8-week study showed that oral intake of celery extract could enhance the 14C-cholesterol/metabolites excretion and lowered serum TC level mainly through increased bile acid excretion but not by modulating the activity of the rate-limiting enzyme for cholesterol biosynthesis, HMG-CoA reductase. Expand
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It can be said that A. graveolens is a potent plant against experimentally induced hepatocarcinogenesis in Wistar rats. Expand
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TLDR
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TLDR
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Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage.
TLDR
It is concluded that liver toxicity induced by TAA is associated with the enhancement of testicular toxicity of DEHP, but not DEHA, in rats, and DEHA treatment was not associated with any apparent testicularoxicity in either TAA- or vehicle-treated animals. Expand
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TLDR
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