The thankless task of playing genetics with mammalian mitochondrial DNA: a 30-year review.

Abstract

The advances obtained through the genetic tools available in yeast for studying the oxidative phosphorylation (OXPHOS) biogenesis and in particular the role of the mtDNA encoded genes, strongly contrast with the very limited benefits that similar approaches have generated for the study of mammalian mtDNA. Here we review the use of the genetic manipulation… (More)

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@article{BayonaBafaluy2002TheTT, title={The thankless task of playing genetics with mammalian mitochondrial DNA: a 30-year review.}, author={Mar{\'i}a Pilar Bayona-Bafaluy and Patricio Fern{\'a}ndez-Silva and Jos{\'e} Alonso Enriquez}, journal={Mitochondrion}, year={2002}, volume={2 1-2}, pages={3-25} }