The thalamostriatal system: a highly specific network of the basal ganglia circuitry

  title={The thalamostriatal system: a highly specific network of the basal ganglia circuitry},
  author={Yoland Smith and Dinesh V. Raju and Jean-François Par{\'e} and Mamadou Sidib{\'e}},
  journal={Trends in Neurosciences},

Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement

The possibility that degeneration of the thalamostriatal system could underlie some of the deficits in redirection of attention in response to salient stimuli seen in Parkinson's disease is addressed.

The cortico-basal ganglia integrative network: The role of the thalamus

Intralaminar Thalamic Nuclei are Main Regulators of Basal Ganglia

The anatomical and metabolic data discussed in this communication clearly support the idea that the intralaminar nuclei cannot longer be seen as a simply relay station between the basal ganglia output nuclei and the cortex.

Thalamostriatal System Controls the Acquisition, Performance, and Flexibility of Learning Behavior

Behavioral studies on thalamostriatal neurons are summarized, showing the key roles of these neurons in different learning processes, such as the acquisition, performance, and flexibility of behavior.

Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum

Thalamostriatal synapses differ in many aspects and the data suggest that inputs from the central lateral nucleus are efficient drivers of medium‐spiny neuron action potential firing, whereas inputsFrom the parafascicular nucleus are likely to be modulatory.

The thalamostriatal system in normal and diseased states

Optogenetic methods and evidence largely gathered from thalamic recordings in awake monkeys strongly suggests that the thalamostriatal system from the CM/Pf is involved in regulating alertness and switching behaviors, and there is evidence that the caudal intralaminar nuclei and their axonal projections to the striatum partly degenerate in PD.



Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum

The organization of the thalamic projections to the ventral striatum in the rat was studied by placing injections of the retrograde tracer cholera toxin subunit B in the ventral striatum and small

The Place of the Thalamus in Frontal Cortical-Basal Ganglia Circuits

This work has shown that the corticothalamic projection is important for the dynamics of the thalamo-cortical processing and the relay nuclei that carry basal ganglia output to the cortex have recently been shown to project back to the basal Ganglia directly.

Efferent connections of the internal globus pallidus in the squirrel monkey: I. topography and synaptic organization of the pallidothalamic projection

To better understand how the segregated functional pathways from the cerebral cortex through the striatopallidal complex emerged in the projections to the thalamus, injections of the retrograde‐anterograde tracer, biotinylated dextran amine (BDA), in different functional regions of the internal pallidum (GPi) in squirrel monkeys were achieved.

Organization of thalamostriatal terminals from the ventral motor nuclei in the macaque

Results suggest that functionally distinct VA/VL projections may also converge in dorsal striatal areas, and raise the possibility thatVA/VL thalamostriatal projections neurons have divergent connectional features.

Nigral and pallidal inputs to functionally segregated thalamostriatal neurons in the centromedian/parafascicular intralaminar nuclear complex in monkey

Findings of this study provide additional evidence for the high degree of functional specificity of the thalamostriatal system through which CM/Pf may provide attention‐specific sensory information important for conditional responses to the primate striatum.