The thalamo-cortical complex network correlates of chronic pain

@article{Zippo2016TheTC,
  title={The thalamo-cortical complex network correlates of chronic pain},
  author={Antonio Giuliano Zippo and Maurizio Valente and Gian Carlo Caramenti and Gabriele E. M. Biella},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Chronic pain (CP) is a condition with a large repertory of clinical signs and symptoms with diverse expressions. Though widely analyzed, an appraisal at the level of single neuron and neuronal networks in CP is however missing. The present research proposes an empirical and theoretic framework which identifies a complex network correlate nested in the somatosensory thalamocortical (TC) circuit in diverse CP models. In vivo simultaneous extracellular neuronal electrophysiological high-density… 
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TLDR
Using fMRI, an analytical pipeline is proposed to study dynamic fMRI brain networks and it is demonstrated that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.
Chronic pain alters microvascular architectural organization of somatosensory cortex
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This research illustrates how the microvessel compartments of the somatosensory cortex in experimental animals present profound and long-lasting signs of extensive neogenesis early within the first two weeks from the CP start, undergoing a slow and incomplete decline within six months.
Removal of behavioural and electrophysiological signs of chronic pain by in vivo microsections of rat somatosensory cortex with parallel X-ray microbeams
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This work preliminary investigated by an in silico accurate simulator of the six-layer mammalian cortical networks that evidenced the crucial collapse of network modularity in CP simulated conditions and the consequent reduction of network adaptive processes.
Cortical microvessels and the tripartite synapse in chronic pain studied with synchrotron radiation
TLDR
The microvascular involvement in CP opens a new way of interpretation of CP disease, not only recognized as sensory pathology, but also as a neurological disease where neuronal and vascular connectivity networks are extensively involved in the whole system.
Abnormal Anatomical and Functional Connectivity of the Thalamo-sensorimotor Circuit in Chronic Low Back Pain: Resting-state Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Study
Nerve Injury Decreases Hyperacute Resting-State Connectivity Between the Anterior Cingulate and Primary Somatosensory Cortex in Anesthetized Rats
TLDR
The results indicated that both SI and ACC are involved in hyperacute pain processing, which was most pronounced in thehyperacute phase but a longer time frame may be required for plastic changes to occur.
Altered evoked low-frequency connectivity from SI to ACC following nerve injury in rats
TLDR
It is shown that both a directed and non-directed connectivity between SI and ACC approach can be used to show the acute changes resulting from the SNI model, likely indicating hypersensitivity of this pathway.
The role of the anterior pretectal nucleus in pain modulation: A comprehensive review
TLDR
This review focuses on rodent anatomical, behavioral, molecular, and neurochemical data that have helped to identify mediators of the anterior pretectal nucleus and pathways related to its role in pain modulation.
Can local-community-paradigm and epitopological learning enhance our understanding of how local brain connectivity is able to process, learn and memorize chronic pain?
TLDR
It is concluded that the local-community-paradigm is a model of complex network organization that triggers a local learning rule, which seems associated to processing, learning and memorization of chronic pain in the brain functional connectivity.
Sevoflurane reduced functional connectivity of excitatory neurons in prefrontal cortex during working memory performance of aged rats.
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