The thalamic reticular nucleus: structure, function and concept

@article{Pinault2004TheTR,
  title={The thalamic reticular nucleus: structure, function and concept},
  author={Didier Pinault},
  journal={Brain Research Reviews},
  year={2004},
  volume={46},
  pages={1-31}
}
  • D. Pinault
  • Published 1 August 2004
  • Biology, Psychology
  • Brain Research Reviews
A search for the searchlight – crossmodal interactions in the reticular thalamic nucleus (Commentary on Kimura)
  • L. Acsády
  • Biology
    The European journal of neuroscience
  • 2014
TLDR
Kimura (2014) convincingly demonstrated that the responses of nRT neurons to light and sound systematically differed when the stimuli were presented separately or together, implying that a stimulus with combined visual and auditory features might increase thalamic output, a property that would fit well with the tasks of a good ‘searchlight’.
Distinct subnetworks of the thalamic reticular nucleus
TLDR
A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.
Behaviorally Modulated Filter Model for the Thalamic Reticular Nucleus
  • A. Scaglione, K. Moxon
  • Biology, Psychology
    2006 International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2006
TLDR
It is demonstrated, for the first time, that the responses of single neurons in the reticular nucleus are modulated by the behavior of the animal, suggesting that the modulation of the responses in the thalamus and cortex could be at least partially due to the TRN through a mechanism that is similar to that of a behavioral modulated filter.
The Cognitive Thalamus as a Gateway to Mental Representations
TLDR
It is proposed that these apparently separate cognitive functions may indeed be supported by a more general role in shaping mental representations, and several features of thalamocortical circuits are consistent with this suggested role.
CIRCUIT DYNAMICS UNDERLYING CONTROL OF DOPAMINE NEURON ACTIVITY BY THE NUCLEUS REUNIENS OF THE MIDLINE THALAMUS
TLDR
A novel role for a corticothalamic circuit including the ilPFC, RE, and vSub in controlling VTA DA neuron firing is revealed and input from ilP FC to RE can modulate RE neuron firing pattern in nuanced and complex ways.
A computational model of intrathalamic signaling via open-loop thalamo-reticular-thalamic architectures
TLDR
The relative capacities of closed- and open-loop TC-TRN-TC synaptic configurations to support both stimulus-evoked propagation and oscillation were evaluated, while simultaneously exploring the possibility that synaptic connections exclusive to the TRN might cooperatively or separately underlie these wave properties.
Interhemispheric Interactions of the Human Thalamic Reticular Nucleus
TLDR
The thalamic reticular nucleus is anatomically identified using multiple registered and averaged proton density-weighted structural MRI scans and drive its functional activity with a dual phase-encoded stimulus to characterize the retinotopic and temporal response properties in the visual sector of the TRN.
Attentional Modulation of Thalamic Reticular Neurons
TLDR
As predicted, TRN activity is modified by shifts of visual attention, and these attentional changes could influence visual processing in LGN via the inhibitory connections back to the thalamus.
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References

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Structure and connections of the thalamic reticular nucleus: Advancing views over half a century
The advance of knowledge of the thalamic reticular nucleus and its connections has been reviewed and Max Cowan's contributions to this knowledge and to the methods used for studying the nucleus have
Functional organization of thalamocortical relays.
TLDR
Although the specific function of the circuits and cellular properties of the thalamic relay for waking behavior is far from clear, two related hypotheses are offered based on recent experimental evidence: one is that theThalamus is not used just to relay peripheral information from, for example, visual, auditory, or cerebellar inputs, but that someThalamic nuclei are arranged instead to relay information from one cortical area to another.
Intrathalamic sensory connections mediated by the thalamic reticular nucleus
  • J. Crabtree
  • Biology
    Cellular and Molecular Life Sciences CMLS
  • 1999
TLDR
It is proposed that, during wakefulness, TRN is crucially involved in resetting the activity levels in sensory nuclei of the dorsal thalamus, which allows the cortex to actively and periodically compare its on-going sensory processing with the available sensory information.
Function of the thalamic reticular complex: the searchlight hypothesis.
  • F. Crick
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
It is suggested that in the brain the internal attentional searchlight, proposed by Treisman and others, is controlled by the reticular complex of the thalamus (including the closely related
Attentional Orienting Is Impaired by Unilateral Lesions of the Thalamic Reticular Nucleus in the Rat
The thalamic reticular nucleus (TRN) has been implicated in attentional processes based on its anatomical, electrophysiological, and neurochemical relationships with the sensory nuclei of the
Anatomical evidence for a mechanism of lateral inhibition in the rat thalamus
TLDR
The relationships between single TC and Rt neurons, which had been marked simultaneously with an anterograde/retrograde tracer (biocytin or Neurobiotin), were examined, in adult rats, using the extracellular or juxtacellular technique.
A STUDY OF THALAMO-CORTICAL RELATIONS
TLDR
A topographical analysis of thalamo-cortical relations as revealed by alterations in the electrocorticogram induced by localized thalamic stimulation is presented, based upon the assumption that the complex spontaneous pattern of the cortex represents an aggregation of various sorts of activity.
Organization in the somatosensory sector of the cat's thalamic reticular nucleus
  • J. Crabtree
  • Biology
    The Journal of comparative neurology
  • 1996
TLDR
There is a dual organization in the projections of cells in the somatosensory sector of TRN to dorsal thalamus: Projections to VB are topographically organized whereas those to ventral POm lack a topographical organization.
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