The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

Abstract

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel α subunit in nociception and pain by constructing sns-null mutant mice. These mice expressed only TTX-sensitive sodium currents on step depolarizations from normal resting… (More)
DOI: 10.1038/9195

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@article{Akopian1999TheTS, title={The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways}, author={Armen N. Akopian and Veronika Souslova and Steven England and Kenji Okuse and Nobukuni Ogata and Jan M. Ure and Andrew James Smith and Bradley James Kerr and Steven B. McMahon and Sue Boyce and Ray Hill and Louise C. Stanfa and Anthony Henry Dickenson and John N. Wood}, journal={Nature Neuroscience}, year={1999}, volume={2}, pages={541-548} }