The tetrodotoxin-resistant Na+ channel Nav1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors

@article{Kistner2010TheTN,
  title={The tetrodotoxin-resistant Na+ channel Nav1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors},
  author={Katrin Kistner and Katharina Schindowski Zimmermann and Corina Ehnert and Peter W Reeh and Andreas Leffler},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2010},
  volume={459},
  pages={751-763}
}
The generation of action potentials in nociceptive neurons is accomplished by the tetrodotoxin-resistant (TTXr) Na+ channel Nav1.8. Following nerve injury, a redistribution of Nav1.8 from dorsal root ganglion (DRG) neurons into peripheral axons contributes to hyperexcitability and possibly to neuropathic pain. Nav1.8 has been reported to display a lower sensitivity to block by Na+ channel blockers as compared to TTX-sensitive (TTXs) Nav subunits. Furthermore, the antinociceptive efficacy of… CONTINUE READING
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