The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.

@article{Unternaehrer2007TheTC,
  title={The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.},
  author={Julia J. Unternaehrer and Amy Chow and Marc Pypaert and Kayo Inaba and Ira Mellman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 1},
  pages={234-9}
}
We have found that MHC class II (MHC II) molecules exhibit a distinctive organization on the dendritic cell (DC) plasma membrane. Both in DC lysates and on the surface of living cells, I-A and I-E molecules engaged in lateral interactions not observed on other antigen-presenting cells such as B blasts. Because DCs and B blasts express MHC II at comparable surface densities, the interaction was not due to simple mass action. Instead, it reflected the selective expression of the tetraspanin CD9… CONTINUE READING