The tetraspanin CD63 is involved in granule targeting of neutrophil elastase.

@article{Kllquist2008TheTC,
  title={The tetraspanin CD63 is involved in granule targeting of neutrophil elastase.},
  author={Linda K{\"a}llquist and Markus Hansson and A M Persson and Hans Janssen and Jero Calafat and Hans Tapper and Inge Olsson},
  journal={Blood},
  year={2008},
  volume={112 8},
  pages={
          3444-54
        }
}
Targeting mechanisms of neutrophil elastase (NE) and other luminal proteins stored in myeloperoxidase (MPO)-positive secretory lysosomes/primary granules of neutrophils are unknown. These granules contain an integral membrane protein, CD63, with an adaptor protein-3-dependent granule delivery system. Therefore, we hypothesized that CD63 cooperates in granule delivery of the precursor of NE (proNE). Supporting this hypothesis, an association was demonstrated between CD63 and proNE upon… 
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