The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.

@article{Franco2010TheTC,
  title={The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.},
  author={M{\'e}lanie Franco and Claudia Muratori and Simona Corso and Enrico Tenaglia and Andrea Bertotti and Lorena Capparuccia and Livio Trusolino and Paolo Maria Comoglio and Luca Tamagnone},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 50},
  pages={38756-64}
}
CD151, a transmembrane protein of the tetraspanin family, is implicated in the regulation of cell-substrate adhesion and cell migration through physical and functional interactions with integrin receptors. In contrast, little is known about the potential role of CD151 in controlling cell proliferation and survival. We have previously shown that β4 integrin, a major CD151 partner, not only acts as an adhesive receptor for laminins but also as an intracellular signaling platform promoting cell… CONTINUE READING

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