The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras.

@article{Sawada2003TheTC,
  title={The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras.},
  author={Shigeaki Sawada and Yoshimoto Mitsunori and Elena Odintsova and Neil A Hotchin and Fedor Berditchevski},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 29},
  pages={
          26323-6
        }
}
Transmembrane proteins of the tetraspanin superfamily are associated with integrins and are thought to regulate adhesion-dependent signaling. The molecular mechanisms of this regulation remain unknown. We used rat fibroblasts to analyze the contribution of the tetraspanin CD151 in the adhesion-dependent signaling. Expression of CD151 specifically attenuated adhesion-dependent activation of Ras. Furthermore, activation of PKB/c-Akt and ERK1/2, downstream targets in the Ras signaling pathway, was… CONTINUE READING

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