The testis-specific beta-tubulin subunit in Drosophila melanogaster has multiple functions in spermatogenesis.

@article{Kemphues1982TheTB,
  title={The testis-specific beta-tubulin subunit in Drosophila melanogaster has multiple functions in spermatogenesis.},
  author={Kenneth J. Kemphues and Thomas C Kaufman and Rudolf A. Raff and Elizabeth C. Raff},
  journal={Cell},
  year={1982},
  volume={31 3 Pt 2},
  pages={655-70}
}
We have isolated four recessive male sterile mutations in the structural gene for the testis-specific Drosophila beta 2-tubulin. Each of these mutations encodes a variant beta 2-tubulin subunit synthesized at normal levels, but which is subsequently unstable and rapidly degraded within the testis. In such testes, the normal alpha tubulins are also synthesized at normal levels and then degraded. Thus in mutant males the testis tubulin pool is drastically reduced relative to wild-type. In males… CONTINUE READING