The testis in adreno-leukodystrophy.

  title={The testis in adreno-leukodystrophy.},
  author={J Michael Powers and Herbert H. Schaumburg},
  journal={The American journal of pathology},
  volume={102 1},
Testicular tissue from 7 juvenile and 6 adult patients with adreno-leukodystrophy (ALD) or its adrenomyeloneuropathic (AMN) variant was examined by light and electron microscopy. The seminiferous tubules of the men exhibited hypocellularity, maturation arrest, or Sertoli cells and spermatogonia only. Ultrastructural examination of these specimens revealed vacuolation of Sertoli cell endoplasmic reticulum. Germ cells also demonstrated vacuolation and necrosis, accompanied by slight tubular… CONTINUE READING