The testicular effects of tumor necrosis factor.

  title={The testicular effects of tumor necrosis factor.},
  author={Kenneth Mealy and Bruce Gregory Robinson and Clarke F Millette and Joseph A. Majzoub and Douglas W. Wilmore},
  journal={Annals of surgery},
  volume={211 4},
Tumor necrosis factor (TNF) is a cytokine that mediates many of the metabolic responses after endotoxemia, septicemia, and tissue injury. The effect of TNF on testicular function was determined in a series of studies in which rhTNF (0, 2, and 4 X 10(5) units/kg/24 hours) was administered by continuous infusion to male Wistar rats maintained on total parenteral nutrition adequate for growing rats. Testicular weight and histology, and plasma luteinizing hormone (LH), follicle-stimulating hormone… CONTINUE READING


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