The tertiary structure of &ggr;c cytokines dictates receptor sharing

  title={The tertiary structure of \&ggr;c cytokines dictates receptor sharing},
  author={Pedro A. Reche},
  • P. Reche
  • Published 1 April 2019
  • Biology, Medicine
  • Cytokine
Graphical abstract Figure. No Caption available. HighlightsThe basis for receptor sharing among &ggr;c cytokines remains to be defined.We obtained and compared the tertiary structures of &ggr;c cytokines.The tertiary structure of &ggr;c cytokines dictates receptor chain sharing.Unlike previously thought, IL‐9 is closer to IL‐2 and IL‐15 than to IL‐7.IL‐7 fold topology resembles that of long‐chain 4‐helix bundle cytokines. ABSTRACT The &ggr;c family of cytokines comprising interleukin‐2 (IL‐2… 
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