The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure.

@article{Osborne2006TheTA,
  title={The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure.},
  author={Simone A. Osborne and H Hawkes and Ben L Baldwin and Kylie Anne Alexander and Terje Svingen and Frank M. Clarke and Kathryn F Tonissen},
  journal={The Biochemical journal},
  year={2006},
  volume={398 2},
  pages={269-77}
}
Thioredoxin is a redox-active protein that plays multiple roles in regulating cell growth, cell signalling and apoptosis. Here, we have demonstrated that a complex mechanism involving multiple regulatory elements is involved in the tBHQ [tert-butylhydroquinone or 2,5-di-(t-butyl)-1,4-hydroquinone]-mediated activation of the thioredoxin gene. Luciferase assays, utilizing various wild-type and mutated thioredoxin promoter fragments, revealed roles for the ORE (oxidative stress responsive element… CONTINUE READING

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