The ternary complex of EF-Tu and its role in protein biosynthesis.

@article{Clark1997TheTC,
  title={The ternary complex of EF-Tu and its role in protein biosynthesis.},
  author={Brian F. C. Clark and Jens Nyborg},
  journal={Current opinion in structural biology},
  year={1997},
  volume={7 1},
  pages={110-6}
}
The past year has seen a breakthrough in our structural understanding of how aminoacyl-tRNAs are selected and transported to the ribosomal A-site in order to decode genetic information contained in messenger RNA. All aminoacyl-tRNAs are recognized by the elongation factor EF-Tu in prokaryotes or EF-1alpha in eukaryotes. The recent determination of the structure of the ternary complex of aminoacyl-tRNA, EF-Tu and a GTP analogue shows how the CCA end of all aminoacyl-tRNA structures can be… CONTINUE READING