The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.

@article{Mattila2009TheTP,
  title={The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.},
  author={Simo Mattila and Hannu Tuominen and John P. Koivukangas and Frej G Stenb{\"a}ck},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2009},
  volume={29 2},
  pages={156-65}
}
Prostaglandin E2 has been connected to processes promoting tumor growth in several human malignancies including gliomas. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES convert PGH2 into prostaglandin E2. The inhibition of their function could significantly reduce PGE2 levels in tumors while avoiding some side effects related to the inhibition of the upstream enzymes COX-1 and COX-2. In this study, the immunohistochemical staining of mPGES-1 and, for the first time, the… CONTINUE READING
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