Topics from this paper
Autism: Animal Models
Because the primary diagnostic criteria of autism are abnormal behaviors, rather than biochemical or neuroanatomical factors, the use of animal models in the study of autism is unavoidable, as this is the only way to study behavioral defects within the context of the whole organism.
Fetal exposure to teratogens: Evidence of genes involved in autism
- Medicine, BiologyNeuroscience & Biobehavioral Reviews
Environmental risk factors for autism
- MedicineEmerging health threats journal
The rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition.
Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model
- MedicineJournal of developmental biology
It is suggested that a future challenge in zebrafish ASD-ID modeling will be to bridge prenatal anatomical and physiological pathologies to behavioral deficits later in life.
Environmental factors influencing the risk of autism
- MedicineJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
A set of environmental factors involved in the occurrence of autism has been collected, and finally, some practical recommendations for reduction of the risk of this devastating disease in children are represented.
The Association Between Autism and Errors in Early Embryogenesis: What Is the Causal Mechanism?
- Biology, MedicineBiological Psychiatry
The search for a fetal origin for autism: Evidence of aberrant brain development in a rat model of autism produced by prenatal exposure to valproate
The results suggest that the VPA-induced animal model of autism can reproduce, at least in part, some anatomopathological findings reported in idiopathic autism, and that such changes are already apparent in the fetal brain.
Animal Models of Autism Spectrum Disorders and Behavioral Techniques of their Examination
Autism spectrum disorders constitute a significant problem in modern neurology and in neuroscience in general. At present, the incidence of such disorders is increasing, reasons for their appearance…
Engrailed2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders
Preliminary data from the laboratory suggest that En2 promotes postnatal cerebellar development via cell cycle regulation and interactions with extracellular growth signals, and underscores the importance of multidisciplinary approaches to identifying ASD-associated genes and their functions during development of brain structures known to be abnormal in ASD patients.
General developmental health in the VPA-rat model of autism
- MedicineFront. Behav. Neurosci.
Observations of the general health of Wistar dams treated with a single intraperitoneal injection of 500 or, 600 mg/kg VPA on embryonic day E12.5 are presented and further documentation of developmental health may guide sub-grouping of individuals in a way to better predict core symptom severity.
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