The teratology of autism

  title={The teratology of autism},
  author={Tara L. Arndt and Christopher J. Stodgell and Patricia M. Rodier},
  journal={International Journal of Developmental Neuroscience},

Autism: Animal Models

Because the primary diagnostic criteria of autism are abnormal behaviors, rather than biochemical or neuroanatomical factors, the use of animal models in the study of autism is unavoidable, as this is the only way to study behavioral defects within the context of the whole organism.

Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model

  • R. Kozol
  • Psychology, Biology
    Journal of developmental biology
  • 2018
It is suggested that a future challenge in zebrafish ASD-ID modeling will be to bridge prenatal anatomical and physiological pathologies to behavioral deficits later in life.

Environmental risk factors for autism

The rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition.

Environmental factors influencing the risk of autism

A set of environmental factors involved in the occurrence of autism has been collected, and finally, some practical recommendations for reduction of the risk of this devastating disease in children are represented.

The search for a fetal origin for autism: Evidence of aberrant brain development in a rat model of autism produced by prenatal exposure to valproate

The results suggest that the VPA-induced animal model of autism can reproduce, at least in part, some anatomopathological findings reported in idiopathic autism, and that such changes are already apparent in the fetal brain.

Animal Models of Autism Spectrum Disorders and Behavioral Techniques of their Examination

This review describes and analyzes the main methodical approaches in modeling of autism spectrum disorders in animals, and behavioral methods used in the studies of these models.

Engrailed2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders

Preliminary data from the laboratory suggest that En2 promotes postnatal cerebellar development via cell cycle regulation and interactions with extracellular growth signals, and underscores the importance of multidisciplinary approaches to identifying ASD-associated genes and their functions during development of brain structures known to be abnormal in ASD patients.

General developmental health in the VPA-rat model of autism

Observations of the general health of Wistar dams treated with a single intraperitoneal injection of 500 or, 600 mg/kg VPA on embryonic day E12.5 are presented and further documentation of developmental health may guide sub-grouping of individuals in a way to better predict core symptom severity.



Embryological origin for autism: Developmental anomalies of the cranial nerve motor nuclei

The autopsy data and experimental data from rats confirm that CNS injuries occurring during or just after neural tube closure can lead to a selective loss of neurons derived from the basal plate of the rhombencephalon.

Autism in children with congenital rubella

  • S. Chess
  • Psychology, Medicine
    Journal of autism and childhood schizophrenia
  • 1971
It is argued that these data support the concept of organic causation of the syndrome of autism and are compared with that found in two epidemiological studies and also with the rate indicated by other centers studying rubella children.

Hypoplasia of cerebellar vermal lobules VI and VII in autism.

In patients with autism, neocerebellar abnormality may directly impair cognitive functions that some investigators have attributed to the neoceebellum; may indirectly affect the development and functioning of one or more systems involved in cognitive, sensory, autonomic, and motor activities.

Autism and Autistic Behavior in Joubert Syndrome

Both total number of DSM-IV symptoms and number of social symptoms distinguished the autism and nonautism subgroups, and the two subgroups displayed similar levels of communication impairments and repetitive or stereotyped behavior.

Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism.

Minor malformations and physical measurements in autism: data from Nova Scotia.

Abnormal ear configuration was the minor malformation most characteristic of the developmental disability group, and the subset of Down syndrome children had single transverse creases of the palm and epicanthic folds that resulted in significantly increased rates of these anomalies in the developmentally disabled controls.

A clinicopathological study of autism.

A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism, finding the likely involvement of the cerebral cortex in autism.

Classical Eyeblink Conditioning in Normal and Autistic Children

The observation that gene knockout mice display a similar profile of facilitated conditioning and short latency CRs suggest that there may be olivocerebellar abnormalities in autism, which may account for some of the behavioral manifestations of autism through deviant cerebellar — forebrain interactions.

Autistic behaviors in offspring of mothers abusing alcohol and other drugs: a series of case reports.

The behavioral characteristics of these children are described and compared with current diagnostic criteria for autistic disorder, and longitudinal scores on the Bayley Scales of Infant Development are provided to underscore the marked developmental delays shown by each of the children.