The teratology of autism

@article{Arndt2005TheTO,
  title={The teratology of autism},
  author={Tara L. Arndt and Christopher J. Stodgell and Patricia M. Rodier},
  journal={International Journal of Developmental Neuroscience},
  year={2005},
  volume={23},
  pages={189-199}
}

Autism: Animal Models

Because the primary diagnostic criteria of autism are abnormal behaviors, rather than biochemical or neuroanatomical factors, the use of animal models in the study of autism is unavoidable, as this is the only way to study behavioral defects within the context of the whole organism.

Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model

  • R. Kozol
  • Psychology, Biology
    Journal of developmental biology
  • 2018
It is suggested that a future challenge in zebrafish ASD-ID modeling will be to bridge prenatal anatomical and physiological pathologies to behavioral deficits later in life.

Environmental risk factors for autism

The rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition.

Environmental factors influencing the risk of autism

A set of environmental factors involved in the occurrence of autism has been collected, and finally, some practical recommendations for reduction of the risk of this devastating disease in children are represented.

The search for a fetal origin for autism: Evidence of aberrant brain development in a rat model of autism produced by prenatal exposure to valproate

The results suggest that the VPA-induced animal model of autism can reproduce, at least in part, some anatomopathological findings reported in idiopathic autism, and that such changes are already apparent in the fetal brain.

Animal Models of Autism Spectrum Disorders and Behavioral Techniques of their Examination

This review describes and analyzes the main methodical approaches in modeling of autism spectrum disorders in animals, and behavioral methods used in the studies of these models.

Engrailed2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders

Preliminary data from the laboratory suggest that En2 promotes postnatal cerebellar development via cell cycle regulation and interactions with extracellular growth signals, and underscores the importance of multidisciplinary approaches to identifying ASD-associated genes and their functions during development of brain structures known to be abnormal in ASD patients.

General developmental health in the VPA-rat model of autism

Observations of the general health of Wistar dams treated with a single intraperitoneal injection of 500 or, 600 mg/kg VPA on embryonic day E12.5 are presented and further documentation of developmental health may guide sub-grouping of individuals in a way to better predict core symptom severity.
...

References

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  • Psychology, Medicine
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It is argued that these data support the concept of organic causation of the syndrome of autism and are compared with that found in two epidemiological studies and also with the rate indicated by other centers studying rubella children.

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